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規(guī)格	庫存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
1 mg	3-5 days	￥1388.00	登錄后可見	- +
5 mg	3-5 days	￥3566.00	登錄后可見	- +

規(guī)格

庫存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

1 mg

3-5 days

￥1388.00

登錄后可見

- +

5 mg

3-5 days

￥3566.00

登錄后可見

- +

基本信息

英文名稱	Brigimadlin (Synonyms: BI 907828)
中文名稱	(3S,3'S,3a'S,10a'S)-6-氯-3'-(3-氯-2-氟苯基)-1'-(環(huán)丙基甲基)-6'-甲基-2-氧代-3',3a',10',10a'-四氫-1'H-螺[吲哚啉-3,2'-吡咯并[2',3':4,5]吡咯并[1,2-b]吲唑]-7'-羧酸
CAS號(hào)	2095116-40-6
分子式	C31H25Cl2FN4O3
分子量	591.46
外觀	White to off-white powder
儲(chǔ)存條件	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

產(chǎn)品詳情

Brigimadlin (BI 907828) is a potent, orally active MDM2-p53 antagonist that inhibits the E3 ubiquitin-protein ligase MDM2, thereby preventing its negative regulation of the tumor suppressor p53. It's used in research for metastatic bile duct cancer, pancreatic cancer, lung adenocarcinoma, and bladder cancer.

相關(guān)文獻(xiàn)

BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models.

PMID: 36521007 PMCID: PMC10158121 DOI: 10.1093/neuonc/noac271

PMID: 38214149 DOI: 10.2217/fon-2023-0963

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CL3062

(3S,3'S,3a'S,10a'S)-6-氯-3'-(3-氯-2-氟苯基)-1'-(環(huán)丙基甲基)-6'-甲基-2-氧代-3',3a',10',10a'-四氫-1'H-螺[吲哚啉-3,2'-吡咯并[2',3':4,5]吡咯并[1,2-b]吲唑]-7'-羧酸

2095116-40-6 98+% 3-5 days

￥1388.00 1 mg

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(3S,3'S,3a'S,10a'S)-6-氯-3'-(3-氯-2-氟苯基)-1'-(環(huán)丙基甲基)-6'-甲基-2-氧代-3',3a',10',10a'-四氫-1'H-螺[吲哚啉-3,2'-吡咯并[2',3':4,5]吡咯并[1,2-b]吲唑]-7'-羧酸

Brigimadlin (Synonyms: BI 907828)

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