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6-乙基-5-((乙硫基)羰基)-2-苯基-4-丙基煙酸丙酯

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MRS 1523 (Synonyms: 3-Propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate)

產(chǎn)品編號(hào):CL1065 CAS No.:212329-37-8 MDLNo: 分子式:C23H29NO3S 分子量:399.55
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基本信息
英文名稱(chēng) MRS 1523 (Synonyms: 3-Propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate)
中文名稱(chēng)6-乙基-5-((乙硫基)羰基)-2-苯基-4-丙基煙酸丙酯
CAS號(hào)212329-37-8
分子式C23H29NO3S
分子量399.55
外觀(guān)Yellowish brown oil
儲(chǔ)存條件Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
產(chǎn)品詳情

MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons. MRS 1523 has been used as an inhibitor of adenosine receptors in SW1990 and BxPC3 pancreatic cancer cells, LX2 human hepatic stellate cells  and human coronary smooth muscle cells. 
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