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規(guī)格	庫存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
20 mg	In-stock	￥360.00	登錄后可見	- +
50 mg	In-stock	￥560.00	登錄后可見	- +
100 mg	In-stock	￥886.00	登錄后可見	- +

規(guī)格

庫存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

20 mg

In-stock

￥360.00

登錄后可見

- +

50 mg

In-stock

￥560.00

登錄后可見

- +

100 mg

In-stock

￥886.00

登錄后可見

- +

基本信息

英文名稱	Tofacitinib (Synonyms: Tasocitinib; CP-690550; 托法替尼; 托法替布)
中文名稱	3-((3R,4R)-4-甲基-3-(甲基(7H-吡咯并[2,3-d]嘧啶-4-基)氨基)哌啶-1-基)-3-氧代丙烷腈
CAS號(hào)	477600-75-2
分子式	C16H20N6O
分子量	312.37
MDL	MFCD11035919
外觀	White or off-white powder
儲(chǔ)存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.

相關(guān)文獻(xiàn)

Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS.

PMID: 28087469 DOI: 10.1016/j.pupt.2017.01.002

PMID: 22899318 DOI: 10.1002/art.34649

PMID: 24890727 PMCID: PMC4106678 DOI: 10.4049/jimmunol.1400063

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CL1120

3-((3R,4R)-4-甲基-3-(甲基(7H-吡咯并[2,3-d]嘧啶-4-基)氨基)哌啶-1-基)-3-氧代丙烷腈

477600-75-2 98+% In-stock

￥360.00 20 mg

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3-((3R,4R)-4-甲基-3-(甲基(7H-吡咯并[2,3-d]嘧啶-4-基)氨基)哌啶-1-基)-3-氧代丙烷腈

Tofacitinib (Synonyms: Tasocitinib; CP-690550; 托法替尼; 托法替布)

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