| 英文名稱 | Halofuginone (Synonyms: Tempostatin; RU-19110) | 
|---|---|
| 中文名稱 | 常山酮; 鹵夫酮; 溴氯哌喹酮 | 
| CAS號 | 55837-20-2 | 
| 分子式 | C16H17BrClN3O3 | 
| 分子量 | 414.68 | 
| 英文名稱 | Halofuginone (Synonyms: Tempostatin; RU-19110) | 
|---|---|
| 中文名稱 | 常山酮; 鹵夫酮; 溴氯哌喹酮 | 
| CAS號 | 55837-20-2 | 
| 分子式 | C16H17BrClN3O3 | 
| 分子量 | 414.68 | 
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.