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首頁 > 產(chǎn)品目錄 > 信號通路 > Immunology & Inflammation > NOD-like Receptor (NLR) > MCC950 Sodium (CP-456773 Sodium)

MCC950 Sodium (CP-456773 Sodium)

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MCC950 Sodium (CP-456773 Sodium)

產(chǎn)品編號：CL1969 CAS No.：256373-96-3 MDLNo： 分子式：C20H23N2NaO5S 分子量：426.46

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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
5 mg	In-stock	￥450.00	登錄后可見	- +
10 mg	In-stock	￥800.00	登錄后可見	- +
25 mg	In-stock	￥1350.00	登錄后可見	- +
50 mg	In-stock	￥2430.00	登錄后可見	- +

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基本信息

英文名稱	MCC950 Sodium (CP-456773 Sodium)
中文名稱	MCC950 Sodium (CP-456773 Sodium)
CAS號	256373-96-3
分子式	C20H23N2NaO5S
分子量	426.46
外觀	Off-white to yellow powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

MCC950 is an inhibitor of NOD-like receptor protein 3 (NLRP3) inflammasome activation. It inhibits ATP-induced IL-1β release in LPS-primed mouse bone marrow-derived macrophages (BMDMs; IC50 = 7.5 nM), as well as cytosolic LPS-induced IL-1β release in Pam3CSK4-primed mouse BMDMs at 0.1 and 1 μM, indicating inhibition of both canonical and non-canonical NLRP3 inflammasome activation, respectively. MCC950 is selective for NLRP3 over NLRC4 and absent in melanoma 2 (AIM2) inflammasomes and does not inhibit LPS-induced NLRP3 priming in mouse BMDMs at 10 μM. It reduces ox-LDL-induced increases in caspase-1 activity and inhibits pyroptosis in THP-1 macrophages when used at a concentration of 1 μM. MCC950 (10 mg/kg) reduces myocardial fibrosis in mice following myocardial infarction induced by left coronary artery ligation. It improves forelimb grip strength and reduces spinal edema in a mouse model of spinal crush injury at the same dose.

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CL1969

MCC950 Sodium (CP-456773 Sodium)

256373-96-3 98+% In-stock

￥450.00 5 mg