| 英文名稱 | Bosutinib(SKI-606) | 
|---|---|
| 中文名稱 | 伯舒替尼 | 
| CAS號(hào) | 380843-75-4 | 
| 分子式 | C26H29Cl2N5O3 | 
| 分子量 | 530.45 | 
| 外觀 | White to light yellow powder | 
| 儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). | 
| 規(guī)格 | 庫(kù)存 | 目錄價(jià) | 會(huì)員專享價(jià) | 數(shù)量 | |
|---|---|---|---|---|---|
| 暫無(wú)牌價(jià)信息,您可以發(fā)送詢價(jià),我們會(huì)盡快給你回復(fù)。 | |||||
| 英文名稱 | Bosutinib(SKI-606) | 
|---|---|
| 中文名稱 | 伯舒替尼 | 
| CAS號(hào) | 380843-75-4 | 
| 分子式 | C26H29Cl2N5O3 | 
| 分子量 | 530.45 | 
| 外觀 | White to light yellow powder | 
| 儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). | 
Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy