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規(guī)格	庫(kù)存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
500 mg	In-stock	￥688.00	登錄后可見(jiàn)	- +
1 g	In-stock	￥1068.00	登錄后可見(jiàn)	- +
5 g	In-stock	￥2688.00	登錄后可見(jiàn)	- +

規(guī)格

庫(kù)存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

500 mg

In-stock

￥688.00

登錄后可見(jiàn)

- +

1 g

In-stock

￥1068.00

登錄后可見(jiàn)

- +

5 g

In-stock

￥2688.00

登錄后可見(jiàn)

- +

基本信息

英文名稱	Temozolomide \| NSC 362856 \| CCRG 81045 \| TMZ
中文名稱	3-甲基-4-氧代-3,4-二氫咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺；替莫唑胺
CAS號(hào)	85622-93-1
分子式	C6H6N6O2
分子量	194.15
MDL	MFCD00866492
外觀	Off-white crystalline powder
儲(chǔ)存條件	-20°C, protect from light, stored under nitroge

產(chǎn)品詳情

1. TMZ(Temozolomide) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.

2.Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects.

相關(guān)文獻(xiàn)

Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site.

PMID: 11877304 DOI: 10.1182/blood.v99.6.2241

PMID: 26447477 PMCID: PMC4598115 DOI: 10.1371/journal.pone.0140131

Neoplasia. 2008 Dec;10(12):1383-92.

PMID: 17968428 PMCID: PMC2360470 DOI: 10.1038/sj.bjc.6604017

PMID: 30405885 PMCID: PMC6201851 DOI: 10.18632/oncotarget.26183

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