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規(guī)格	庫(kù)存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
10 mg	In-stock	￥328.00	登錄后可見(jiàn)	- +
25 mg	In-stock	￥568.00	登錄后可見(jiàn)	- +

規(guī)格

庫(kù)存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

10 mg

In-stock

￥328.00

登錄后可見(jiàn)

- +

25 mg

In-stock

￥568.00

登錄后可見(jiàn)

- +

基本信息

英文名稱	Everolimus \| RAD-001
中文名稱	(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-二羥基-3-((R)-1-((1S,3R,4R)-4-(2-羥基乙氧基)-3-甲氧基環(huán)己基)丙-2-基)-10,21-二甲氧基-6,8,12,14,20,26-六甲基-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-十六氫-3H-23,27-環(huán)氧吡啶并[21-c][1]氧雜]4]氮雜環(huán);依維莫司
CAS號(hào)	159351-69-6
分子式	C53H83NO14
分子量	958.22
MDL	MFCD00929329
外觀	White to off-white powder
儲(chǔ)存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

Everolimus, also known as RAD001, is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.

相關(guān)文獻(xiàn)

Biomarker Development for the Clinical Activity of the mTOR Inhibitor Everolimus (RAD001): Processes,Limitations, and Further Proposals.

PMID: 20360931 PMCID: PMC2847314 DOI: 10.1593/tlo.09277

PMID: 19223496 DOI: 10.1158/1078-0432.CCR-08-2057

PMID: 29077243 PMCID: PMC5765289 DOI: 10.1111/cas.13431

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CL2331

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-二羥基-3-((R)-1-((1S,3R,4R)-4-(2-羥基乙氧基)-3-甲氧基環(huán)己基)丙-2-基)-10,21-二甲氧基-6,8,12,14,20,26-六甲基-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-十六氫-3H-23,27-環(huán)氧吡啶并[21-c][1]氧雜]4]氮雜環(huán);依維莫司

159351-69-6 98+% In-stock

￥328.00 10 mg

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Everolimus | RAD-001

化學(xué)品安全說(shuō)明書(shū)(MSDS)

質(zhì)檢證書(shū)(COA)