日本乱熟人妻精品乱码涩爱,欧美一区二区三区蜜臀,欧美一级特级a毛一片

規(guī)格	庫(kù)存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
5 mg	In-stock	￥276.00	登錄后可見(jiàn)	- +
10 mg	In-stock	￥466.00	登錄后可見(jiàn)	- +
25 mg	In-stock	￥746.00	登錄后可見(jiàn)	- +
50 mg	In-stock	￥1198.00	登錄后可見(jiàn)	- +

規(guī)格

庫(kù)存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

5 mg

In-stock

￥276.00

登錄后可見(jiàn)

- +

10 mg

In-stock

￥466.00

登錄后可見(jiàn)

- +

25 mg

In-stock

￥746.00

登錄后可見(jiàn)

- +

50 mg

In-stock

￥1198.00

登錄后可見(jiàn)

- +

基本信息

英文名稱	MG-132 (Synonyms: Z-Leu-Leu-Leu-al; MG132)
中文名稱	N-[(芐氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-L-亮氨酰胺
CAS號(hào)	133407-82-6
分子式	C26H41N3O5
分子量	475.62
MDL	MFCD00674886
外觀	White to yellow powder
儲(chǔ)存條件	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

產(chǎn)品詳情

MG-132, a potent proteasome and calpain inhibitor, boasts IC50s of 100 nM and 1.2 μM, respectively. This peptide aldehyde effectively halts the 26S proteasome complex's proteolytic activity. Beyond its inhibitory role, MG-132 activates autophagy and triggers apoptosis. Studies reveal that MG-132 can activate autophagy in vascular smooth muscle cells, inhibiting senescence through the PI3K/AKT/mTOR pathway. It also induces apoptosis in a cell cycle-dependent manner, highlighting its multifaceted bioactivity in cellular regulation.

相關(guān)文獻(xiàn)

MG132-induced progerin clearance is mediated by autophagy activation and splicing regulation.

PMID: 28674081 PMCID: PMC5582415 DOI: 10.15252/emmm.201607315

PMID: 26987571 PMCID: PMC4968607 DOI: 10.1111/cas.12926

PMID: 24584782 PMCID: PMC4020493 DOI: 10.3892/ijmm.2014.1678

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N-[(芐氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲?；?3-甲基丁基]-L-亮氨酰胺

133407-82-6 98+% In-stock