英文名稱 | Decitabine | Dacogen | NSC 127716 |
---|---|
中文名稱 | 地西他濱 |
CAS號 | 2353-33-5 |
分子式 | C8H12N4O4 |
分子量 | 228.21 |
外觀 | White to off white crystalline powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Decitabine | Dacogen | NSC 127716 |
---|---|
中文名稱 | 地西他濱 |
CAS號 | 2353-33-5 |
分子式 | C8H12N4O4 |
分子量 | 228.21 |
外觀 | White to off white crystalline powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.
PMID: 23671644 PMCID: PMC3650049 DOI: 10.1371/journal.pone.0062924
PMID: 29708513 PMCID: PMC5983332 DOI: 10.1172/JCI97924
The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine.
PMID: 27325794 DOI: 10.1042/BCJ20160302