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鹽酸厄洛替尼 | 埃羅替尼鹽酸鹽

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Erlotinib Hydrochloride (Synonyms: Erlotinib HCl; CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride; OSI-774 HCl)

產(chǎn)品編號:CL2423 CAS No.:183319-69-9 MDLNo: 分子式:C22H23N3O4·HCl 分子量:429.90
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基本信息
英文名稱 Erlotinib Hydrochloride (Synonyms: Erlotinib HCl; CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride; OSI-774 HCl)
中文名稱鹽酸厄洛替尼 | 埃羅替尼鹽酸鹽
CAS號183319-69-9
分子式C22H23N3O4·HCl
分子量429.90
外觀White to off-white powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Erlotinib HCl (formerly OSI-744, OSI744; trade name: Tarceva), the hydrochloride salt of erlotinib, is an EGFR (epidermal growth factor receptor) inhibitor with antitumor activity. In cell-free experiments, it inhibits EGFR with an IC50 of 2 nM, and when compared to human c-Src or v-Abl, it is >1000 times more sensitive to inhibit EGFR. The FDA and other nations have authorized erlotinib, a quinazoline derivative, for the treatment of pancreatic cancer, non-small cell lung cancer (NSCLC), and various other cancer types.
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