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基本信息

英文名稱	A-484954; 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide
中文名稱	7-氨基-1-環(huán)丙基-3-乙基-2,4-二氧代-1,2,3,4-四氫吡啶并[2,3-d]嘧啶-6-甲酰胺
CAS號	142557-61-7
分子式	C13H15N5O3
分子量	289.29
MDL	MFCD22683836

產(chǎn)品詳情

A-484954 is a highly selective eukaryotic elongationfactor-2 kinase(eEF2K) inhibitor, with an IC₅₀ of 280 nM.
A cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
Keywords: buy A-484954 | A-484954 supplier | purchase A-484954 | A-484954 cost | A-484954 manufacturer | order A-484954 | A-484954 distributor | Eukaryotic elongation factor-2 kinase inhibitor | eEF2K Inhibitor

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CL2604

7-氨基-1-環(huán)丙基-3-乙基-2,4-二氧代-1,2,3,4-四氫吡啶并[2,3-d]嘧啶-6-甲酰胺

142557-61-7 98+%

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7-氨基-1-環(huán)丙基-3-乙基-2,4-二氧代-1,2,3,4-四氫吡啶并[2,3-d]嘧啶-6-甲酰胺

A-484954; 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide

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