| 英文名稱 | Tesirine | SG3249 | 
|---|---|
| 中文名稱 | 特司林 | 
| CAS號 | 1595275-62-9 | 
| 分子式 | C75H101N9O23 | 
| 分子量 | 1496.65 | 
| 外觀 | White to light yellow powder | 
| 儲存條件 | Avoid light, nitrogen, -20 ℃ | 
| 英文名稱 | Tesirine | SG3249 | 
|---|---|
| 中文名稱 | 特司林 | 
| CAS號 | 1595275-62-9 | 
| 分子式 | C75H101N9O23 | 
| 分子量 | 1496.65 | 
| 外觀 | White to light yellow powder | 
| 儲存條件 | Avoid light, nitrogen, -20 ℃ | 
Tesirine (SG-3249; SG3249), cathepsin B-cleavable valine-alanine pyrrolobenzodiazepine (PBD) dimer used as an antibody-drug conjugate (ADC) payload; Tesirine was designed to combine the potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. Rovalpituzumab tesirine is a first-in-class ADC directed against delta-like protein 3 (DLL3), a novel target identified in tumour-initiating cells and expressed in small-cell lung cancer.
PMID: 29992976 PMCID: PMC6041317 DOI: 10.1038/s41598-018-28533-4