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規(guī)格	庫存	目錄價(jià)	會員專享價(jià)	數(shù)量
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規(guī)格

庫存

目錄價(jià)

會員專享價(jià)

數(shù)量

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基本信息

英文名稱	BLU9931
中文名稱	BLU9931
CAS號	1538604-68-0
分子式	C26H22Cl2N4O3
分子量	509.38
外觀	Off-white to light yellow powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

BLU9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor xenograft that overexpresses FGF19 mRNA but lacks FGF19 amplification. Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho β (KLB) could potentially respond to treatment with an FGFR4 inhibitor.

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BLU9931

BLU9931

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