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RMC-6236 | RAS-IN-2

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RMC-6236 (Synonyms: RAS-IN-2)

產(chǎn)品編號：CL2789 CAS No.：2765081-21-6 MDLNo： 分子式：C43H56N8O5S 分子量：797.02
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
1 mg 3-5 days ￥2366.00 登錄后可見
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5 mg 3-5 days ￥5788.00 登錄后可見
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10 mg 3-5 days ￥9388.00 登錄后可見
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基本信息
英文名稱 RMC-6236 (Synonyms: RAS-IN-2)
中文名稱RMC-6236 | RAS-IN-2
CAS號2765081-21-6
分子式C43H56N8O5S
分子量797.02
外觀White to off-white powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
RMC-6236 is an orally active, non-covalent RAS (ON) inhibitor. RMC-6236 disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC50 values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. RMC-6236 inhibits pERK. RMC-6236 has anti-tumor activity against KRAS mutant tumors.
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