| 英文名稱 | GNE-9815 |
|---|---|
| 中文名稱 | GNE-9815 |
| CAS號 | 2729996-45-4 |
| 分子式 | C26H22FN5O2 |
| 分子量 | 455.48 |
| 外觀 | Off-white to light yellow powder |
| 儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
| 英文名稱 | GNE-9815 |
|---|---|
| 中文名稱 | GNE-9815 |
| CAS號 | 2729996-45-4 |
| 分子式 | C26H22FN5O2 |
| 分子量 | 455.48 |
| 外觀 | Off-white to light yellow powder |
| 儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
GNE-9815 (compound 7) is a highly selective, orally bioavailable pan-RAF inhibitor. For CRAF and BRAF, respectively, GNE-9815 displays Ki values of 0.062 and 0.19 nM. The MAPK pathway is modulated synergistically when GNE-9815 and the MEK inhibitor Cobimetinib are combined. Cancers with the KRAS mutation can be studied using GNE-9815.