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基本信息

英文名稱	TAK-715
中文名稱	TAK-715
CAS號	303162-79-0
分子式	C24H21N3OS
分子量	399.51
外觀	White to off-white powder
儲存條件	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

產品詳情

TAK-715 is an orally active and potent p38 MAPK inhibitor with IC₅₀s of 7.1 nM, 200 nM for p38α and p38β, respectively. TAK-715 inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis mode.

相關文獻

Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

PMID: 16162000 DOI: 10.1021/jm050165o

Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/?.

PMID: 21513885 DOI: 10.1016/j.chembiol.2011.01.015

Inhibition of α1-adrenoceptor reduces TGF-β1-induced epithelial-to-mesenchymal transition and attenuates UUO-induced renal fibrosis in mice.

PMID: 32939891 DOI: 10.1096/fj.202000737RRR

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