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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
1 mg	3-5days	￥488.00	登錄后可見	- +
5 mg	3-5days	￥1686.00	登錄后可見	- +
10 mg	3-5days	￥2236.00	登錄后可見	- +

規(guī)格

庫存

目錄價

會員專享價

數(shù)量

1 mg

3-5days

￥488.00

登錄后可見

- +

5 mg

3-5days

￥1686.00

登錄后可見

- +

10 mg

3-5days

￥2236.00

登錄后可見

- +

基本信息

英文名稱	Milciclib \| PHA-848125
中文名稱	嘧西利 \| 米爾西利
CAS號	802539-81-7
分子式	C25H32N8O
分子量	460.57
外觀	Light yellow to yellow powder
儲存條件	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

產(chǎn)品詳情

Milciclib is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7, it's also an inhibitor of TRKA with IC50 of 53nM. Milciclib (PHA-848125) induces cell death through autophagy.

相關(guān)文獻

Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor.

PMID: 19603809 DOI: 10.1021/jm9006559

Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.

PMID: 22704958 DOI: 10.1016/j.bcp.2012.06.004

Dual targeting of CDK and tropomyosin receptor kinase families by the oral inhibitor PHA-848125, an agent with broad-spectrum antitumor efficacy.

PMID: 20682657 DOI: 10.1158/1535-7163.MCT-10-0190

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