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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
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規(guī)格

庫存

目錄價

會員專享價

數(shù)量

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基本信息

英文名稱	BAN ORL 24 2HCl \| BAN-ORL-24 2HCl
中文名稱	BAN ORL 24 2HCl \| BAN-ORL-24 2HCl
CAS號	1401463-54-4
分子式	C27H35N3O2·2HCl
分子量	506.51 \| 433.60 (free)
外觀	White to off-white powder
儲存條件	-20°C, protect from light, stored under nitrogen

產(chǎn)品詳情

BAN ORL 24 is an antagonist of the nociceptin (NOP) receptor (K_i = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor). It is selective for NOP receptors over μ-, δ-, and κ-opioid receptors (K_is = 0.19, 0.34, and >1 μM, respectively). BAN ORL 24 reduces NOP-induced GTPγS binding (pA₂ = 9.98) and calcium mobilization (K_B = 0.93 nM) in CHO cells. It inhibits electrically induced twitches in isolated mouse and rat vas deferens, as well as isolated guinea pig ileum, when used at a concentration of 100 nM. BAN ORL 24 (10 mg/kg) reverses thermal and mechanical antinociceptive activities induced by the dual agonist of μ-opioid and NOP receptors BPR1M97 in mice.

https://doi.org/10.1016/j.neuropharm.2019.107678

PMID: 19445927 DOI: 10.1016/j.ejphar.2009.04.054

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BAN ORL 24 2HCl | BAN-ORL-24 2HCl

1401463-54-4 98+%

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BAN ORL 24 2HCl | BAN-ORL-24 2HCl

BAN ORL 24 2HCl | BAN-ORL-24 2HCl

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