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基本信息

英文名稱	Vicriviroc maleate (Synonyms: SCH-417690 maleate ; SCH-D maleate; 維立韋羅馬來酸鹽）
中文名稱	1-[(4,6-二甲基-5-嘧啶基)羰基]-4-[(3s)-4-[(1r)-2-甲氧基-1-[4-(三氟甲基)苯基]乙基]-3-甲基-1-哌嗪基]-4-甲基哌啶馬來酸鹽
CAS號	599179-03-0
分子式	C28H38F3N5O2·C4H4O4
分子量	649.70 \| 533.64(free)
MDL	MFCD09833218
外觀	White to off-white powder
儲存條件	4°C, sealed storage, away from moisture

產(chǎn)品詳情

Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in clinical development for the treatment of HIV-1.

相關文獻

Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1.

PMID: 16304152 PMCID: PMC1315929 DOI: 10.1128/AAC.49.12.4911-4919.2005

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist.

PMID: 15115380 DOI: 10.1021/jm0304515

Effect of Vicriviroc on the QT/Corrected QT Interval and Central Nervous System in Healthy Subjects.

PMCID: PMC2876383 PMID: 20350942

Science Direct: Novel targets for anti-retroviral therapy.

https://doi.org/10.1016/j.jinf.2009.09.014