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規(guī)格	庫(kù)存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
1 mg	3-5 days	￥1488.00	登錄后可見(jiàn)	- +
2 mg	3-5 days	￥2266.00	登錄后可見(jiàn)	- +
5 mg	3-5 days	￥3626.00	登錄后可見(jiàn)	- +

規(guī)格

庫(kù)存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

1 mg

3-5 days

￥1488.00

登錄后可見(jiàn)

- +

2 mg

3-5 days

￥2266.00

登錄后可見(jiàn)

- +

5 mg

3-5 days

￥3626.00

登錄后可見(jiàn)

- +

基本信息

英文名稱	Lapaquistat acetate (Synonyms: TAK-475)
中文名稱	2-(1-(2-((3R,5S)-1-(3-乙酰氧基-2,2-二甲基丙基)-7-氯-5-(2,3-二甲氧基苯基)-2-氧代-1,2,3,5-四氫苯并[e][1,4]氧氮雜卓-3-基)乙?；?哌啶-4-基)乙酸
CAS號(hào)	189060-13-7
分子式	C33H41ClN2O9
分子量	645.14
MDL	MFCD06407873
外觀	White to off-white powder
儲(chǔ)存條件	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

產(chǎn)品詳情

Lapaquistat acetate, a potent squalene synthase inhibitor, impedes the conversion of farnesyl diphosphate (FPP) to squalene, a key step in cholesterol synthesis. Utilized in treating Mevalonate Kinase Deficiency (MKD), an autosomal recessive disorder, it significantly reduces low-density lipoprotein cholesterol levels. However, its use may be accompanied by liver damage, a known side effect that warrants monitoring.

相關(guān)文獻(xiàn)

Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice

PMID: 28901277 DOI: 10.2174/0929867324666170911161417

Br J Pharmacol. 2008 Jul;154(5):949-57.

PMID: 21518985 DOI: 10.1161/CIRCULATIONAHA.110.975284

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CL3134

2-(1-(2-((3R,5S)-1-(3-乙酰氧基-2,2-二甲基丙基)-7-氯-5-(2,3-二甲氧基苯基)-2-氧代-1,2,3,5-四氫苯并[e][1,4]氧氮雜卓-3-基)乙?；?哌啶-4-基)乙酸

189060-13-7 98+% 3-5 days

￥1488.00 1 mg

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2-(1-(2-((3R,5S)-1-(3-乙酰氧基-2,2-二甲基丙基)-7-氯-5-(2,3-二甲氧基苯基)-2-氧代-1,2,3,5-四氫苯并[e][1,4]氧氮雜卓-3-基)乙?；?哌啶-4-基)乙酸

Lapaquistat acetate (Synonyms: TAK-475)

化學(xué)品安全說(shuō)明書(shū)(MSDS)