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基本信息

英文名稱	Anti-Human EGFRxMET Bispecific Antibody(Amivantamab; JNJ-61186372)
中文名稱	埃萬妥單抗
CAS號(hào)	2171511-58-1
儲(chǔ)存條件	-20°C for 3 years \| In solvent: -80°C for 1 year

產(chǎn)品詳情

Amivantamab (JNJ-61186372) is a fully human EGFR-MET bispecific antibody that combats resistance in NSCLC through multifaceted mechanisms: ligand blockade, receptor degradation, and immune cell activation, including ADCC and trogocytosis. This innovative approach targets both primary and acquired resistance, offering a new therapeutic avenue for patients with EGFR and MET aberrations.

相關(guān)文獻(xiàn)

Amivantamab in EGFR Exon 20 Insertion-Mutated Non-Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study.

PMID: 34339292 PMCID: PMC8791812 DOI: 10.1200/JCO.21.00662

PMID: 32414908 DOI: 10.1158/2159-8290.CD-20-0116

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埃萬妥單抗

Anti-Human EGFRxMET Bispecific Antibody(Amivantamab; JNJ-61186372)

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